李毅 副教授 硕士生导师
E-mail: liyi@sxau.edu.cn
个人简介
李毅（1992-05），博士，副教授，山西运城人，中共党员。主讲课程为《微生物学》、《应用微生物》和《环境生物学》。目前主要从事环境微生物分子生态学研究。通过宏基因组学、全基因组学以及培养组学技术研究环境微生物多样性、基因组进化及其生态适应机制，重点研究环境微生物资源的分类以及抗生素抗性基因(ARGs)的赋存特征与迁移机制。在Environmental Microbiology、Science of the Total Environment、Frontiers in Microbiology、International Journal of Systematic and Evolutionary Microbiology、Scientific Reports、Marine Genomics、微生物学报、生物多样性等期刊上发表论文20余篇。
学习和工作经历
2010.09 – 2014.06 内蒙古民族大学 学士 生物技术
2014.09 – 2019.06 山东大学 硕博连读 微生物学
2019.07 – 2022.07 山西农业大学 必威Betway东盟体育 讲师
2022.07 – 至今 山西农业大学 必威Betway东盟体育 副教授
目前研究方向
1. 环境微生物的资源分类与功能鉴定
探索微生物培养组学技术，借助于可培养方法挖掘新型菌株（图1），在菌株水平对环境微生物进行功能特性与生态适应机制研究，为深入认识环境微生物生理生化特征及生态功能提供了菌株资源，并将其作为物种库与功能基因库进行资源开发和应用。
图1. 马里亚纳海沟水生微生物的AFM和SEM观察
2. 环境抗生素抗性基因的赋存特征与迁移机制
基于宏基因组测序技术，研究河流以及极端地区抗生素抗性基因（ARGs）的分布、传播、扩散与持久性残留等环境行为及其影响因素（图2）。
图2. 南极地区抗生素耐药性的发生机制
发表论文
[1] Yi Li, Xiao-Meng Sun, Yan-Ru Dang, Ning-Hua Liu, Qi-Long Qin, Yu-Qiang Zhang*, Xi-Ying Zhang*. Genomic analysis of Marinomonas profundi M1K-6T reveals its adaptation to deep-sea environment of the Mariana Trench. Marine Genomics, 2022, 62: 100935.
[2] Yi Li*, Yun-Yun Ding, Yan-Ru Dang, Yun Bai, Li Guan, Ning-Hua Liu, Yu-Zhu Wang, Mei-Lin Kang, YuQiang Zhang*, Xi-Ying Zhang*. Celeribacter litoreus sp. nov., isolated from intertidal sediment. International Journal of Systematic and Evolutionary Microbiology, 2022, 72: 005241.
[3] 夏呈强, 李毅*, 党延茹, 察倩倩, 贺晓艳, 秦启龙. 中印度洋与南海西部表层海水细菌多样性. 生物多样性, 2022, 30 (1): 21407.
[4] 李毅, 夏呈强, 冯焱, 李宏, 张锋, 关丽, 董凯诗, 申少斐*.通过宏基因组分箱方法揭示南极联合冰川土壤中ARG宿主. 生态学杂志, 2021, 40(9):2832-2841.
[5] 李毅, 张利环, 冯焱, 李宏, 张锋, 白芸, 丁云云, 康美琳, 王雨竹, 雷嘉轩, 申少斐*. 基于宏基因组技术解析南极不同纬度地区土壤抗生素抗性基因的分布与迁移. 微生物学报, 2021, 61(11):3744-3756.
[6] 李毅*, 党研茹, 任雪冰, 察倩倩, 秦启龙, 夏呈强, 冯焱, 李宏, 张锋. 马里亚纳海沟可培养水生细菌的多样性. 微生物学报, 2021, 61(6): 1383-1398.
[7] Yi Li#, Zhi-Bin Wang#, Xi-Ying Zhang, Yan-Ru Dang, Lin-Lin Sun, Wei-Peng Zhang, Hui-Hui Fu, Gui-Peng Yang, Min Wang, Andrew McMinn, Xiu-Lan Chen, Yin Chen, Shi Wang, Yu-Zhong Zhang, Qi-Long Qin*. Experimental evidence for long-term coexistence of copiotrophic and oligotrophic bacteria in pelagic surface seawater. Environmental Microbiology, 2021, 23(2):1162-1173.
[8] Yi Li#, Xiao-Meng Sun#, Jian Li, Xiao-Yan Song, Qi-Long Qin, Hai-Nan Su, Xiu-Lan Chen, Yu-Zhong Zhang, Shou-Jin Fan*, Xi-Ying Zhang*. Marinomonas profundi sp. nov., isolated from deep seawater of the Mariana Trench. International Journal of Systematic and Evolutionary Microbiology, 2020, 70: 5747-5752.
[9] Yi Li, Qian-Qian Cha, Yan-Ru Dang, Xiu-Lan Chen, Min Wang, Andrew Mcminn, Giannina Espina, Yu-Zhong Zhang, Jenny Blamey, Qi-Long Qin*. Reconstruction of the functional ecosystem in the high light, low temperature Union Glacier region, Antarctica. Frontiers in Microbiology, 2019, 10:2408
[10] Yi Li, Lin-Lin Sun, Yuan-Yuan Sun, Qian-Qian Cha, Chun-Yang Li, Dian-Li Zhao, Xiao-Yan Song, Min Wang, Andrew McMinn, Xiu-Lan Chen, Yu-Zhong Zhang, Qi-Long Qin*. Extracellular enzyme activity and its implications for organic matter cycling in northern Chinese marginal seas, Frontiers in Microbiology, 2019, 10:2137
[11] Yi Li, Bai-Lu Tang, Xue-Bing Ren, Yan-Ru Dang, Lin-Lin Sun, Xi-Ying Zhang, Xiu-Lan Chen, Qi-Long Qin, Peng Wang*. Complete genome sequence of Flavobacterium arcticum SM1502T, exhibiting adaption to the Arctic marine salty environment. Marine Genomics, 2019, 47: 100670
[12] Yi Li, Lin-Lin Sun, Mei-Ling Sun, Hai-Nan Su, Xi-Ying Zhang, Bin-Bin Xie, Xiu-Lan Chen, Yu-Zhong Zhang, Qi-Long Qin*. Vertical and horizontal biogeographic patterns and major factors affecting bacterial communities in the open South China Sea. Scientific Reports, 2018, 8(1):8800
[13] Yi Li, Xiao-Han Guo, Yan-Ru Dang, Lin-Lin Sun, Xi-Ying Zhang, Xiu-Lan Chen, Qi-Long Qin, Peng Wang*. Complete genome sequence of Arcticibacterium luteifluviistationis SM1504T, a cytophagaceae bacterium isolated from Arctic surface seawater. Standards in Genomic Sciences, 2018, 13:33
[14] Xiangying Wang, Yi Li, Ying Wei, Huisheng Meng, Yanzhuan Cao, J R Lead, Jianping Hong*. Effects of fertilization and reclamation time on soil bacterial communities in coal mining subsidence areas. Science of the Total Environment, 2020, 739:139882
[15] Zhi-Bin Wang, Yuan-Yuan Sun, Yi Li, Xiu-Lan Chen, Peng Wang, Hai-Tao Ding, Bo Chen, Xi-Ying Zhang, Xiao-Yan Song, Min Wang, Andrew McMinn, Yu-Zhong Zhang, Qi-Long Qin*. Significant bacterial distance-decay relationship in continuous, well-connected Southern Ocean surface water. Microbial Ecology, 2020, 80: 73-80.
[16] Qi-Long Qin, Yi Li, Lin-Lin Sun, Zhi-Bin Wang, Shi Wang, Xiu-Lan Chen, Aharon Oren, Yu-Zhong Zhang*. Tophic specialization results in genomic reduction in free-living marine bacteria. mBio, 2019, 10(1): e02545-18
[17] Yan-Ru Dang, Yuan-Yuan Sun, Lin-Lin Sun, Xiao-Xue Yuan, Yi Li, Qi-Long Qin, Xiu-Lan Chen, Yu-Zhong Zhang, Mei Shi, Xi-Ying Zhang*. Muricauda nanhaiensis sp. nov., isolated from seawater of the South China Sea. International Journal of Systematic and Evolutionary Microbiology, 2019, 69: 2089-2094
[18] Lin-Lin Sun, Yan-Ru Dang, Yi Li, Qi-Long Qin, Hai-Nan Su, Ping-Yi Li, Xiu-Lan Chen, Yu-Zhong Zhang, Xi-Ying Zhang*. Parvularcula marina sp. nov., isolated from surface water of the South China Sea, and emended description of the genus Parvularcula. International Journal of Systematic and Evolutionary Microbiology, 2019, 69: 2571-2576
[19] Jiwei Tian, Lu Fan, Haodong Liu, Jiwen Liu, Yi Li, Qilong Qin, Zheng Gong, Hongtao Chen, Zhongbin Sun, Li Zou, Xuchen Wang, Hongzhou Xu, Douglas Bartlett, Min Wang, Yu-Zhong Zhang, Xiao-Hua Zhang, Chuanlun Zhang. A nearly uniform distributional pattern of heterotrophic bacteria in the Mariana Trench interior. Deep-Sea Research Part I. 2018, 142:116-126
[20] Yu-Zhong Zhang*, Yi Li, Bin-Bin Xie, Xiu-Lan Chen, Qiong-Qiong Yao, Xi-Ying Zhang, Megan L. Kempher, Jizhong Zhou, Aharon Oren, Qi-Long Qin*. Nascent Genomic Evolution and Allopatric Speciation of Myroides profundi D25 in Its Transition from Land to Ocean. mBio, 2016.01.12, 7(1): e01946-15
[21] Jin-Cheng Rong, Min Liu, Yi Li, Tian-Yong Sun, Bin-Bin Xie, Mei Shi, Xiu-Lan Chen, Qi-Long Qin*. Insight into the genome sequence of a sediment-adapted marine bacterium Neptunomonas antarctica S3-22T from Antarctica. Marine Genomics, 2016, 25:29-31
[22] Jin-Cheng Rong, Min Liu, Yi Li, Tian-Yong Sun, Xiu-Hua Pang, Qi-Long Qin, Xiu-Lan Chen, Bin-Bin Xie*. Complete genome sequence of a marine bacterium with two chromosomes, Pseudoalteromonas translucida KMM 520T. Marine Genomics, 2016, 26:17-20
[23] Qi-Long Qin, Yi Li, Mei-Ling Sun, Jin-Cheng Rong, Sheng-Bo Liu, Xiu-Lan Chen, Hai-Nan Su, Bai-Cheng Zhou, Bin-Bin Xie, Yu-Zhong Zhang, Xi-Ying Zhang*. Comparative Transcriptome Analysis Reveals That Lactose Acts as an Inducer and Provides Proper Carbon Sources for Enhancing Exopolysaccharide Yield in the Deep-Sea Bacterium Zunongwangia profunda SM-A87. PLoS One, 2015, 10;2:e0115998
专利
1. 实用新型专利：李毅，罗碧，冯焱. 一种用于海洋水质检测的样品过滤装置， ZL202020851275.7
2. 实用新型专利：李毅，罗碧，夏呈强. 一种用于海洋浮游生物的采集装置，专利号：ZL202020850206.4
主持科研项目
1. 山西省基础研究计划（自由探索类）项目，20210302124004，汾河入黄口沉积物抗生素耐药细菌的赋存特征及其耐药机制研究，2021/12-2025/01
2. 山西省高等学校科技创新项目，2021L134，汾河入黄口沉积物抗生素抗性基因的赋存特征及抗性机制研究，2021/09-2023/09
3. 山西农业大学科技创新基金项目，2020BQ39，汾河流域不同生活方式细菌多样性研究，2020/06-2023/05
4. 山西省优秀博士来晋工作奖励资金科研项目，SXYBKY2019025，抗生素抗性细菌的资源分类与抗性机制研究，2020/01-2021/12
参与科研项目
1. 国家自然科学基金面上项目，31971535，木霉驱动的根际微生物群落变化及其生态机制的宏组学研究
2. 国家自然科学基金面上项目，31870101，三甲胺和氧化三甲胺在深海细菌Myroides profundi D25适应高盐、高压环境中的作用与机制
3. 国家自然科学基金重点项目，31630012，玫瑰杆菌Roseobacter参与海洋表层有机硫DMSP循环机制及生理生态学适应的生物化学基础
学生培养
1. 山西农业大学教学改革研究项目，JG-202226，基于“赛教融合”的微生物学实验教学探索与实践，2022/06-2024/06
2. 指导本科生参加中国科学技术协会主办的第七届全国青年科普创新大赛（2021年）
1) 成绩
太原赛区（山西省、河北省），三等奖1项，优秀奖2项目
2) 部分作品展示
3) 参赛队员
